Transgenic mouse technology, including embryonic stem cell and gene knockout techniques, has revolutionized the study of endocrinology by giving endocrinologists an effective set of tools for understanding endocrine physiology and pathology in vivo. In Transgenics in Endocrinology, a panel of expert clinical and basic investigators summarize the state-of-the-art in the use of this powerful technology in a broad range of endocrinological applications. These applications include studies of mammalian sexual differentiation, steroidogenesis, progesterone action in vivo, normal mammary gland development, oxytocin and vasopressin, regulation and function, skeletal biology, and prostate cancer. There are also transgenic studies of the control of ovarian function, the Bcl2 gene family, c-kit/kit ligand axis in mammalian gametogenesis, prolactin and the prolactin receptor, insulin and insulin-like growth factors, and overexpression and targeted disruption of genes involved in the control of growth, food intake, and obesity. Uptodate and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology, and its pathologies, through mouse models, and provides a host of creative approaches to better understand the complex processes characteristic of hormonal systems.

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Humana Press in Springer Science + Business Media
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InhaltsangabeGermline Genetic Engineering Techniques in Endocrinology Albert S. Y. Chang, Michael J. Reardon, and Francesco J. DeMayo The Transgenic Mouse in Studies of Mammalian Sexual Differentiation Deanne J. Whitworth and Richard R. Behringer The In Vivo Function of Müllerian-Inhibiting Substance During Mammalian Sexual Development Yuji Mishina Control of Ovarian Function Julia A. Elvin and Martin M. Matzuk Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression Emiliana Borrelli, T. Rajendra Kumar, and Paolo Sassone-Corsi Functional Analysis of the Bcl2 Gene Family in Transgenic Mice Andrea J. Ross and Grant R. MacGregor The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis Peter J. Donovan and Maria P. de Miguel Gene Knockout Approaches to Steroidogenesis Tomonobu Hasegawa, Liping Zhao, Kathleen M. Caron, Morag Young, and Keith L. Parker The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo John P. Lydon, Selma Soyal, Bert W. O'Malley, Preeti M. Ismail Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development Tiffany N. Seagroves and Jeffrey M. Rosen Prolactin and the Prolactin Receptor Nelson D. Horseman Transgenic Models for Oxytocin and Vasopressin Larry J. Young and Thomas R. Insel Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function Ruth A. Keri and John H. Nilson Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation Daniel J. Bernard and Teresa K. Woodruff Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System Malcolm J. Low, Marcelo Rubinstein, and E. Cheng Chan Overexpression and Targeted Disruption of Genes Involved inthe Control of Growth, Food Intake, and Obesity Andrzej Bartke and Michael Michalkiewicz Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors Carolyn A. Bondy and Domenico Accili Use of Transgenic Animals in Skeleton Biology Thomas Günther, Mary Jo Doherty, and Gerard Karsenty Transgenic Mouse Models of Prostate Cancer Robert J. Matusik, Naoya Masumori, Tania Thomas, Thomas Case, Manik Paul, Susan Kasper, and Scott B. Shappell Neural and EndocrineCellSpecific Immortalization Using Transgenic Approaches T. Rajendra Kumar