New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art Omics approaches and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models.  As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.

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Humana Press in Springer Science + Business Media
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InhaltsangabePart I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse   1. New Frontiers in Animal Research of Psychiatric Illness             Arie Kaffman and John J. Krystal   2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview             Scott Edwards and George F. Koob   3. Qualitative Vs. Quantitative Methods in Psychiatric Research             Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang,Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold   Part II: Methods in Animal Models of Psychiatric Illness   4. Animal Models of Self-Injurious Behavior: An Overview             Darragh P. Devine   5. Rodent Models of Adaptive Decision Making             Alicia Izquierdo  and Annabelle M. Belcher   6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis             Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O¿Donnell   7. Modeling Depression in Animal Models             David H. Overstreet   8. Behavioral Model for Assessing Cognitive Decline             Michael Guidi and Thomas C. Foster   9. The Pemoline Model of Self-Injurious Behavior             Darragh P. Devine   10. Modeling Risky Decision Making in Rodents             Nicholas W. Simon and Barry Setlow   11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes             Abdelkader Ennaceur   12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia             Mahendra Bishnoi and Ravneet K. Boparai   Part III: Methods in Animal Models of Substance Abuse   13. Models of Chronic Alcohol Exposure and Dependence             Darin J. Knapp and George R. Breese   14. Rat Models of Prenatal and Adolescent Cannabis Exposure             Jennifer A. DiNieri and Yasmin L. Hurd   15. Modeling Nicotine Addiction in Rats             Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador   16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal             Rayna M. Bauzo and Adrie W. Bruijnzeel   17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms             Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang   18. Cocaine Self-Administration in Rats: Hold Down Procedures             Benjamin A. Zimmer and David C.S. Roberts   19. Cocaine Self-Administration in Rats: Discrete Trials Procedures             Carson V. Dobrin and David C.S. Roberts   20. Cocaine Self-Administration in Rats: Threshold Procedures             Erik B. Oleson and David C.S. Roberts   21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents             Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore   22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure             Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy   Part IV: Methods in Animal Models of Eating Disorders   23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight             Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel   24. Animal Models of Overeating             Neil E. Rowland   25. The Activity-Based Anorexia Mouse Model             Stephanie J. Klenot ...

Part I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse   1. New Frontiers in Animal Research of Psychiatric Illness             Arie Kaffman and John J. Krystal   2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview             Scott Edwards and George F. Koob   3. Qualitative Vs. Quantitative Methods in Psychiatric Research             Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang,Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold   Part II: Methods in Animal Models of Psychiatric Illness   4. Animal Models of Self-Injurious Behavior: An Overview             Darragh P. Devine   5. Rodent Models of Adaptive Decision Making             Alicia Izquierdo  and Annabelle M. Belcher   6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis             Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O¿Donnell   7. Modeling Depression in Animal Models             David H. Overstreet   8. Behavioral Model for Assessing Cognitive Decline             Michael Guidi and Thomas C. Foster   9. The Pemoline Model of Self-Injurious Behavior             Darragh P. Devine   10. Modeling Risky Decision Making in Rodents             Nicholas W. Simon and Barry Setlow   11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes             Abdelkader Ennaceur   12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia             Mahendra Bishnoi and Ravneet K. Boparai   Part III: Methods in Animal Models of Substance Abuse   13. Models of Chronic Alcohol Exposure and Dependence             Darin J. Knapp and George R. Breese   14. Rat Models of Prenatal and Adolescent Cannabis Exposure             Jennifer A. DiNieri and Yasmin L. Hurd   15. Modeling Nicotine Addiction in Rats             Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador   16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal             Rayna M. Bauzo and Adrie W. Bruijnzeel   17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms             Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang   18. Cocaine Self-Administration in Rats: Hold Down Procedures             Benjamin A. Zimmer and David C.S. Roberts   19. Cocaine Self-Administration in Rats: Discrete Trials Procedures             Carson V. Dobrin and David C.S. Roberts   20. Cocaine Self-Administration in Rats: Threshold Procedures             Erik B. Oleson and David C.S. Roberts   21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents             Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore   22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure             Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy   Part IV: Methods in Animal Models of Eating Disorders   23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight             Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel   24. Animal Models of Overeating             Neil E. Rowland   25. The Activity-Based Anorexia Mouse Model             Stephanie J. Klenotich and Stephanie C. Dulawa   Part V: Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders   26. Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models             Amy S. Kohtz and Cheryl A. Frye   ...