Beschreibung
The first book on this young, highly dynamic, and expanding field.
This comprehensive, interdisciplinary text focuses on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures.
The authors cover all aspects of pathogenomics, including methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis.
This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.
Autorenportrait
Jörg Hacker studied biology and performed his doctoral thesis at the Martin-Luther-University of Halle in 1979. He was appointed as Associate Professor in the year 1988 and as Full Professor and Chair for Molecular Biology of Infectious Diseases at the University of Würzburg in 1993. His research interests center on the analysis of pathogenic bacteria and their host organisms, and his laboratory described the first pathogenicity islands as early as the start of the nineties. Jörg Hacker is a member of numerous academies and scientific societies and holds positions on several research bodies. He has received many awards, and was made Honorary Doctor by the University of Umea, Sweden, in 2002 and by the University of Pecs, Hungary, in 2004.
Ulrich Dobrindt graduated with a degree in biology from the University of Göttingen (1995) and a PhD in microbiology (1999) from the University of Würzburg. He received a PhD scholarship from the Boehringer Ingelheim Fonds, and went on to carry out research on gene regulation in uropathogenic E. coli before becoming group leader of the Pathogenic Enterobacteria group at the Institute for Molecular Biology of Infectious Diseases working on enterobacterial genome plasticity focusing on extraintestinal pathogenic E. coli.
Inhalt
INTRODUCTION
METHODS
Bioinformatics
Transcriptome analysis
Proteome analysis
Mutational analysis / in vivo tests
GENOMICS OF PATHOGENIC BACTERIA
Enterobacteria
Streptococci /
Enterococci
Staphylococci
Mycobacteria
Neisseria
Pseudomonas (human pathogens)
Clostridia /
Bacillus
Rickettsia /
Bartonella
Xanthomonas / plant pathogenic bacteria
GENOMICS OF PATHOGENS AND THER HOSTS -
APPLICATIONS
Virogenomics
Genomics of pathogenic fungi
Genomics of pathogenic parasites
Model host systems
Expression analysis of human genes during infection
Application, new diagnostic tools
New antibiotics
Reversed vaccinology
Genomics and bioterror
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