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Folding and Unfolding Mechanism of Designed Ankyrin Repeat Proteins

Erschienen am 26.07.2015, 1. Auflage 2015
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Bibliografische Daten
ISBN/EAN: 9783838105062
Sprache: Deutsch
Umfang: 104 S.
Format (T/L/B): 0.7 x 22 x 15 cm
Einband: kartoniertes Buch

Beschreibung

The protein folding problem, i.e. understanding the detailed steps of the protein folding pathways is one of the most challenging topics in biochemistry. Combining theoretical with experimental research became indispensable for the investigation of the mechanisms in protein folding reactions. Here, the biophysical characterization of designed ankyrin repeat (AR) proteins and the analysis of the experimental data by theoretical models are presented. Repeat proteins comprise repeating structural units that form linear multirepeat arrays. The non-globular elongated structure distinguishes them fundamentally from most studied proteins and makes repeat proteins interesting for folding studies. In a previous work, a full-consensus ankyrin repeat had been designed. Such an idealized ankyrin repeat served as a model repeat to study the folding mechanism of ankyrin repeat proteins.

Produktsicherheitsverordnung

Hersteller:
Books on Demand GmbH
bod@bod.de
In de Tarpen 42
DE 22848 Norderstedt

Autorenportrait

Svava Kim Wetzel, Dr. sc. nat. : M. sc. inbiochemistry/biotechnology at Eberhard-Karls-University Tübingen (D) and Ecole Supérieure deBiotechnologie de Strasbourg (F), PhD studies in protein folding with Prof. A. Plückthun,University of Zurich (CH), Promotion 2008. Postdoc in NMR-spectroscopy with Prof. O. Zerbe,University of Zurich (CH)

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