This book is a festschrift to mark the career of ogy, immunology and clinical aspects of each Dr David Tyrrell, eminent virologist and group. There are also more general chapters physician. Almost all of the contributors have overviewing the clinical manifestations, treat been colleagues or students at some time ment and pathophysiology of respiratory during his career. Unlike most festschrifts, virus infections. In addition, chapters in however, the essays have been integrated to which psychological aspects and the ethical produce a comprehensive book that covers use of human volunteers are discussed will be the entire field of non-bacterial infections of of interest to all those involved with respira the human respiratory tract. This is a measure tory infectious agents. of the breadth of interest of the research We hope also that this book serves as a undertaken by David, spanning a period of fitting tribute to a man who is a true poly over 40 years. math: a physician, researcher, teacher, We hope that this book will be of interest mentor, linguist and ambassador for science, to microbiologists, virologists and in particu among other things. To those of us who have lar, to physicians. All the major virus groups contributed to this book, he is even more: a are covered, as well as chlamydial and friend.

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InhaltsangabePreface. Epidemiology of respiratory tract infections. The clinical spectrum of disease in adults. Clinical spectrum of disease in children. Diagnosis of viral respiratory tract infections. Pathophysiology of viral respiratory tract infections. Chronic respiratory infections. Taxonomy of common cold viruses. Respiratory virus infections in the tropics. Rhinoviruses. Coronaviruses. Adenoviruses. Parainfluenza viruses. Influenza viruses - biology. Influenza viruses- clinical spectrum and management. Respiratory syncytial virus. Immunity to respiratory syncytial virus infections. Mycoplasma. Chlamydia. Respiratory virus infections in the immunocompromised. The use of interferons as therapeutic agents. Specific antiviral therapy. Antiviral activity of defective interfering virus - an experimental approach. Psychology of common colds and other infections. The ethical use of human volunteers in clinical research. Index.